decoupler.run_mlm
- decoupler.run_mlm(mat, net, source='source', target='target', weight='weight', batch_size=10000, min_n=5, verbose=False, use_raw=True)
Multivariate Linear Model (MLM).
Wrapper to run MLM.
- Parameters:
- matlist, pd.DataFrame or AnnData
List of [features, matrix], dataframe (samples x features) or an AnnData instance.
- netpd.DataFrame
Network in long format.
- sourcestr
Column name in net with source nodes.
- targetstr
Column name in net with target nodes.
- weightstr
Column name in net with weights.
- batch_sizeint
Size of the samples to use for each batch. Increasing this will consume more memmory but it will run faster.
- min_nint
Minimum of targets per source. If less, sources are removed.
- verbosebool
Whether to show progress.
- use_rawbool
Use raw attribute of mat if present.
- Returns:
- Returns mlm activity estimates and p-values or stores them in mat.obsm[‘mlm_estimate’] and mat.obsm[‘mlm_pvals’].